experts from the Center for the study of inflammation, VIB-UGent and the University of Ghent (Belgium) discovered the mechanism underlying colorectal cancer. Doctors have found that it is directly related to intestinal microorganisms.
the Researchers found that abnormal expression of Zeb2 protein affects the integrity of the intestinal epithelium, which normally functions as a barrier to prevent the penetration of intestinal bacteria. Zeb2 is undermining this barrier, which causes inflammation and eventually leads to the development of cancer.
the Scientists noted that the timely removal of the microbiota or the manipulation of the immune system can prevent the development of cancer. So, the experiment on mice showed that treatment of rodents with broad-spectrum antibiotics failed to destroy certain bacteria and prevent the development of a malignant tumor.
– there is increasing evidence that microbes in our gut play a Central role. In particular, in the development of diseases which are associated with distinct changes in the composition of the microbiota, including colorectal cancer, the expert noted.
Experts have reminded that in addition to genetic factors the risk of developing colon cancer increase poor diet, obesity and sedentary lifestyle.
